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The present study examined the impact of an educational intervention programme on the knowledge and attitude on disadvantaged adolescents in Northern India and Thailand. The study intends to assess and compare the knowledge about the process of growing up, HIV/AIDS awareness, values and attitude of teen-age students studying in the schools in the age of groups from 13 to 16 years. Data was collected by administering with an experimental design consisted of experimental and control group, an educational intervention programme consisting of awareness activities presented through media presentation, discussion, and interaction was presented to the experimental group. Universals and multivariate analysis of the data were used to assess the impact of interventions and to identify the predictors of change in knowledge and attitude. Discussion, the HIV/AIDS, drug abuse and reproductive health needs of disadvantaged adolescents are either poorly understood or not fully appreciated it evidence is growing that this neglect can seriously jeopardize and needs and future well-being of them. The policies addressed the effectiveness of the programmed to highlights what there needs to be done to promote and protect to the disadvantaged adolescent in the future as: all schools should develop textbooks making learning interesting by following extensive community sensitization in support of adolescent reproductive health education appropriate the cultural and tradition. Because of it adolescents kept learning by them long time ago that, made them grow up in the wrong life and have been against morality. Mostly adolescent problems erupt from families and by themselves after they have been sexually abused or because their families could not understand adolescent behavior and teach them about reproductive health education and sexual health education. Such as should improve in knowledge and attitude among school-going adolescents with the media modern of families. In addition, it was found that sexually abused violated in Indian and Thai adolescents should learn and practice self-protection and should gather knowledge of the Child Rights and much more. Conclusions India, the responsible organizations both governmental and non-governmental of India have to develop policies for adolescent and should to include HIV/AIDS education and health programme in schools curriculums. In addition, those reproductive health educational services for adolescent girls are especially needed in schools and families. Moreover, Parents, families, teachers and administrators in orphanages or schools should be encouraged to discuss or give guidance and approval about reproductive health education, drug and HIV/AIDS with their disadvantaged adolescent. Thailand, the reproductive and sexual health education should be included in the curriculum for the second level – primary education (Grades 4-6). It is too late to start from Third level – secondary education (Grades 1-3), thus; the Ministry of Education has to prepare a new policy to put this subject at the Basic Education Curriculum Standard as soon as possible. In addition it appears that in Thailand media has caused a change in sex related values among adolescents with the misuse of Internet in getting information on sex related issue supplemented by the Medias and Booklets are increasing Crime problems of sexually abused. Thus, the quality of the textbooks or booklets to be distributed should be improved to increase the knowledge and understanding of adolescents about reproductive health education and sexual health education.